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KMID : 1039920230300040102
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Neonatal Medicine
2023 Volume.30 No. 4 p.102 ~ p.107
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Beta Thalassemia Presenting with Neonatal Cholestasis and Extensive Hemosiderosis: A Case Report
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Jung Chung-Gang
Lee Jang-Hoon
Kim Yu-Bin
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Abstract
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Neonatal cholestasis is caused by various forms of liver injury and has a complex etiological background. Among these, cases of severe cholestasis due to primary hemolytic disease are rare. Herein, we report a case in which thalassemia-induced severe hemolysis caused bile duct injury by hemosiderosis, with cholestasis occurring shortly after birth and lasting for >4 months. In addition, complete recovery of liver pathology was observed both biochemically and histologically. Hence, clinicians should consider hemolytic disease as a rare cause of neonatal cholestasis in the differential diagnosis of neonates as well as the advisability of conservative treatment based on case progression.
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KEYWORD
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Cholestasis, Hemosiderosis, Beta thalassemia, Hemoglobinopathies, Hemolysis
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